The tricyclic tertiary amine doxepin (Zonalon, Prudox), a potent H1- and H2-receptor antagonist, is indicated for the short-term relief of pruritus associated with topical eczematous dermatitis. Systemic absorption occurs, and the drug may potentiate or alter the metabolism of a variety of other systemic agents. Drowsiness is the most common adverse side effect.
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