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What are the metabolic factors that affect antagonism of neuromuscular blockade?
Respiratory acidosis and metabolic alkalosis increase the depth of neuromuscular blockade and make antagonism more difficult. Postoperative respiratory acidosis of some degree is common in patients following general anesthesia.
Hypothermia, hypokalemia, hypermagnesemia, and hypocalcemia may each decrease the likelihood of success-fully antagonizing neuromuscular blockade.
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