What are
the metabolic factors that affect antagonism of neuromuscular blockade?
Respiratory acidosis and metabolic alkalosis
increase the depth of neuromuscular blockade and make antagonism more
difficult. Postoperative respiratory acidosis of some degree is common in
patients following general anesthesia.
Hypothermia, hypokalemia, hypermagnesemia, and
hypocalcemia may each decrease the likelihood of success-fully antagonizing
neuromuscular blockade.
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