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Chapter: Clinical Cases in Anesthesia : NonDepolarizing NeuroMuscular Blockade

Describe the mechanism by which nondepolarizing neuromuscular blockers produce neuromuscular blockade

Nondepolarizing muscle relaxants produce neuromus-cular blockade by several mechanisms:

Describe the mechanism by which nondepolarizing neuromuscular blockers produce neuromuscular blockade.

 

Nondepolarizing muscle relaxants produce neuromus-cular blockade by several mechanisms:

 

·  They compete with acetylcholine for the α subunit of the acetylcholine receptor on the postjunctional membrane.

 

·  They competitively inhibit acetylcholine from stimulat-ing its receptor at the motor endplate.

 

·  There is also evidence that they block prejunctional acetylcholine receptors, decreasing acetylcholine release in response to motor nerve stimulation.

 

·  Noncompetitive blockade of open postjunctional acetyl-choline channels plays a minor role as well.

 

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Clinical Cases in Anesthesia : NonDepolarizing NeuroMuscular Blockade : Describe the mechanism by which nondepolarizing neuromuscular blockers produce neuromuscular blockade |


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