Describe
the mechanism by which nondepolarizing neuromuscular blockers produce
neuromuscular blockade.
Nondepolarizing muscle relaxants produce
neuromus-cular blockade by several mechanisms:
·
They
compete with acetylcholine for the α subunit of the acetylcholine receptor on the
postjunctional membrane.
·
They
competitively inhibit acetylcholine from stimulat-ing its receptor at the motor
endplate.
·
There is
also evidence that they block prejunctional acetylcholine receptors, decreasing
acetylcholine release in response to motor nerve stimulation.
·
Noncompetitive
blockade of open postjunctional acetyl-choline channels plays a minor role as
well.
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