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What are the determinants of blood pressure?
Mean arterial pressure (MAP) is determined by the cardiac output (CO) and the systemic vascular resistance (SVR) as follows:
MAP = [ CO × SVR] / 80
CO is the product of the stroke volume (SV) and the heart rate (HR) and depends on preload (the end-diastolic myocardial fiber stretch), contractility (the forcefulness of the contraction), and afterload (the tension developed by the fibers during the contraction). A reduction in either cardiac output or systemic vascular resistance without a counteractive change in the other will tend to decrease the blood pressure.
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