Home | | Pathology | Vagina - Pathology

Chapter: Pathology: Female Genital Pathology

| Study Material, Lecturing Notes, Assignment, Reference, Wiki description explanation, brief detail |

Vagina - Pathology

Vaginal adenosis and clear cell adenocarcinoma are rare conditions with increased risk in females exposed to diethylstilbestrol (DES) in utero.

VAGINA

 

         Vaginal adenosis and clear cell adenocarcinoma are rare conditions with increased risk in females exposed to diethylstilbestrol (DES) in utero.

 

         Embryonal rhabdomyosarcoma (sarcoma botryoides) affects infants and young children (age <5), in whom it can cause a polypoid, “grapelike,” soft tissue mass that protrudes from the vagina. Microscopically, the mass is character-ized by polypoid epithelial growth with an underlying immature (cambium) proliferation of spindle-shaped tumor cells with rare cross-striations. Tumor cells are positive for desmin.

 

         Primary forms of vaginal squamous cell carcinoma are usually related to HPV infection; secondary forms are more common and are usually due to extension from a cervical cancer. Treatment is radiotherapy.

 

         Rhabdomyoma is a benign skeletal muscle tumor that can involve the vagina. It occurs in middle-aged women..

         Gartner duct cyst is a cyst of the lateral wall of the vagina that is due to persis-tence of a mesonephric (Wolffian) duct remnant. Urinary tract abnormalities may exist.

 

         Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is congenital absence of the upper part of the vagina and uterus. Patients present with primary amen-orrhea.

 

         Vaginitis/vaginosis: All of the following conditions require vaginal swab for definitive diagnosis; molecular diagnostic tests may be indicated in certain situations.

 

o   Vulvovaginal candidiasis can occur spontaneously or from antibiotic therapy; it is not usually sexually transmitted. Symptoms include dis-charge and pruritis. Yeast cells and pseudohyphae are seen on micros-copy. Antimycotics are therapeutic.

 

o   Bacterial vaginosis (BV) is implicated in preterm labor and pelvic inflammatory disease. Some patients are asymptomatic. BV is a sexually transmitted bacterial infection of polymicrobial origin (although it used to be attributed only to Gardnerella vaginalis); recurrence rate is high after treatment with antibiotics. “Clue cells” are squamous cells coated with coccobacilli that may be seen microscopically in swab material.

 

 

o   Trichomonis vaginalis is a sexually transmitted motile protozoan. Most infected people are asymptomatic. It can also cause cervicitis, but “strawberry cervix” is not a consistent diagnostic feature. Antibiotics are therapeutic.

 

Study Material, Lecturing Notes, Assignment, Reference, Wiki description explanation, brief detail


Copyright © 2018-2020 BrainKart.com; All Rights Reserved. Developed by Therithal info, Chennai.