Streptomycin is the antibiotic of choice for treatment of tula-remia. Gentamicin is used as an alternative to streptomycin. Fluoroquinolones are now increasingly used in treatment of tularemia. Tetracycline and chloramphenicol have been used, but treatments with these bacteriostatic agents have been asso-ciated with high rate of relapse.
Avoidance of exposure to tick bites and to dead or wild mammals, if possible, prevents the disease. Frequent and thorough hand washing is also useful.
Postexposure prophylaxis using tetracycline, ciprofloxacin, or doxycycline for 2 weeks is recommended within 24 hours of air-borne exposure.