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Chapter: Microbiology and Immunology: Immunodeficiency

T-Cell Deficiencies

Acquired immunodeficiency syndrome (AIDS), Measles.

T-Cell Deficiencies

 Acquired immunodeficiency syndrome (AIDS)

Patients with AIDS caused by HIV are highly susceptible to infection by many opportunistic pathogens including bac-teria, viruses, fungi, and parasites. This is attributed to the loss of helper T-cell activity. The virus specifically infects and kills the cells bearing CD4 surface receptors. The immu-nity is highly suppressed, and failure of immune surveil-lance leads to a high incidence of tumors.



T-cell function is altered, but immunoglobulins are normal in patients suffering from measles. Patients show a temporary suppression of delayed hypersensitivity.

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