H. pylori is a gram-negative bacterium that’s thought to be a ma-jor causative factor in the formation of peptic ulcers and gastritis (inflammation of the stomach lining). Eradication of the bacteria helps to heal ulcers and decrease their recurrence
Successful treatment involves the use of two or more antibiotics in combination with other drugs such as acid suppressants. Sys-temic antibiotics used to treat H. pylori include:
Systemic antibiotics are variably absorbed from the GI tract.
Food, especially dairy products, decreases the absorption of tetra-cycline but doesn’t significantly delay the absorption of the other antibiotics.
All of these antibiotics are distributed widely and are excreted pri-marily in urine.
Antibiotics act by treating the H. pylori infection. They’re usually combined with an H2-receptor antagonist or a proton pump in-hibitor to decrease stomach acid and further promote healing.
They are indicated for H. pylori eradication to reduce the risk of a duodenal ulcer. For this reason they may be used in conjunction with other medications such as proton pump inhibitors
Successful treatment plans use at least two antibiotics and a pro-ton pump inhibitor for 14 days and then use a proton pump in-hibitor for 6 more weeks to help reduce acid in patients with a peptic ulcer.
§ Tetracycline and metronidazole can interact with many other med-ications.
§ Tetracycline increases digoxin levels.
§ Metronidazole and tetracycline increase the risk of bleeding when taken with oral anticoagulants.
§ Metronidazole can cause a severe reaction when combined with alcohol. (See Adverse reactions to antibiotics.)