Antiflatulents disperse gas pockets in the GI tract. They’re avail-able alone or in combination with antacids. A major antiflatulent drug currently in use is simethicone.
Antiflatulents aren’t absorbed from the GI tract. They’re distrib-uted only in the intestinal lumen and are eliminated intact in stool.
Antiflatulents provide defoaming action in the GI tract. By produc-ing a film in the intestines, simethicone disperses mucus-enclosed gas pockets and helps prevent their formation.
Antiflatulents are prescribed to treat conditions in which excess gas is a problem, such as:
· functional gastric bloating
· postoperative gaseous bloating
· diverticular disease
· spastic or irritable colon
· air swallowing.
Simethicone doesn’t interact significantly with other drugs and doesn’t cause known adverse reactions.