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Chapter: Clinical Pharmacology: Gastrointestinal drugs

Antiflatulent drugs

Antiflatulents disperse gas pockets in the GI tract. They’re avail-able alone or in combination with antacids. A major antiflatulent drug currently in use is simethicone.

Antiflatulent drugs

Antiflatulents disperse gas pockets in the GI tract. They’re avail-able alone or in combination with antacids. A major antiflatulent drug currently in use is simethicone.

Pharmacokinetics

 

Antiflatulents aren’t absorbed from the GI tract. They’re distrib-uted only in the intestinal lumen and are eliminated intact in stool.

Pharmacodynamics

 

Antiflatulents provide defoaming action in the GI tract. By produc-ing a film in the intestines, simethicone disperses mucus-enclosed gas pockets and helps prevent their formation.

Pharmacotherapeutics

 

Antiflatulents are prescribed to treat conditions in which excess gas is a problem, such as:

 

·                 functional gastric bloating

 

·                 postoperative gaseous bloating

 

·                 diverticular disease

 

·                 spastic or irritable colon

 

·                 air swallowing.

 

Drug interactions

Simethicone doesn’t interact significantly with other drugs and doesn’t cause known adverse reactions.

 

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Clinical Pharmacology: Gastrointestinal drugs : Antiflatulent drugs |


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