Sympathetic and Parasympathetic
“Tone”
Normally, the sympathetic and parasympathetic systems are
continually active, and the basal rates of activity are known, respectively, as
sympathetic tone and parasympathetic tone.
The value of tone is that it
allows a single nervoussystem both to increase and to decrease the activity of
a stimulated organ. For instance, sympathetic tone nor-mally keeps almost
all the systemic arterioles con-stricted to about one half their maximum
diameter. By increasing the degree of sympathetic stimulation above normal,
these vessels can be constricted even more; conversely, by decreasing the
stimulation below normal, the arterioles can be dilated. If it were not for the
continual background sympathetic tone, the sym-pathetic system could cause only
vasoconstriction, never vasodilation.
Another interesting example of tone is the back-ground “tone” of
the parasympathetics in the gastrointestinal tract. Surgical removal of the
parasym-pathetic supply to most of the gut by cutting the vagus nerves can
cause serious and prolonged gastric and intestinal “atony” with resulting
blockage of much of the normal gastrointestinal propulsion and consequent
serious constipation, thus demonstrating that parasympathetic tone to the gut
is normally very much required. This tone can be decreased by the brain,
thereby inhibiting gastrointestinal motility, or it can be increased, thereby
promoting increased gastrointesti-nal activity.
Tone
Caused by Basal Secretion of Epinephrine and Norepi-nephrine by the Adrenal
Medullae. The normal restingrate of secretion by the adrenal medullae is
about 0.2 mg/kg/min of epinephrine and about 0.05 mg/kg/min of norepinephrine.
These quantities are considerable— indeed, enough to maintain the blood
pressure almost up to normal even if all direct sympathetic pathways to the
cardiovascular system are removed. Therefore, it is obvious that much of the
overall tone of the sympa-thetic nervous system results from basal secretion of
epinephrine and norepinephrine in addition to the tone resulting from direct
sympathetic stimulation.
Effect
of Loss of Sympathetic or Parasympathetic Tone After Denervation. Immediately after a
sympathetic orparasympathetic nerve is cut, the innervated organ loses its
sympathetic or parasympathetic tone. In the case of the blood vessels, for
instance, cutting the sym-pathetic nerves results within 5 to 30 seconds in
almost maximal vasodilation. However, over minutes, hours, days, or weeks, intrinsic tone in the smooth muscle of
the vessels increases—that is, increased tone caused by increased smooth muscle
contractile force that is not the
result of sympathetic stimulation but of chemical adaptations in the smooth
muscle fibers themselves. This intrinsic tone eventually restores almost normal
vasoconstriction.
Essentially the same effects occur in most other effector organs
whenever sympathetic or parasympa-thetic tone is lost. That is, intrinsic
compensation soon develops to return the function of the organ almost to its
normal basal level. However, in the parasympa-thetic system, the compensation
sometimes requires many months. For instance, loss of parasympathetic tone to
the heart after cardiac vagotomy increases the heart rate to 160 beats per
minute in a dog, and this will still be partially elevated 6 months later.
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