Pheochromocytoma is associated with what other syndromes?
This tumor arises from neural crest cells and is considered neuroendocrine in origin. Thus, diseases of other neuroendocrine tissues or organs are associated with a higher incidence of pheochromocytoma. MEN types II and are syndromes that include pheochromocytomas. MEN II is a triad of medullary cancer of the thyroid, parathyroid adenoma, and pheochromocytoma. MEN III includes pheochromocytoma and medullary cancer of the thyroid in addition to mucocutaneous syndromes, multiple neuromas (von Recklinghausen’s disease), marfanoid habitus, and hypertrophied corneal nerves. Pheochromocytomas are also seen in association with von Hippel-Lindau syndrome, which includes cerebral and retinal angiomatosis, pancreatic and renal cysts, and epididymal cystadenoma. When caring for patients with these associated conditions, one should maintain a high degree of suspicion for the presence of a pheochromocytoma.