Oesophageal disorders
Gastro-oesophageal reflux occurs
when there is inappropriate effort-less passage of gastric contents into the
oesophagus. GORD exists when reflux is repeated and severe enough to cause
harm. Reflux is very com-mon in infancy and is associated with slow gastric
emptying, liquid diet (milk), horizontal posture, and low resting lower
oesophageal sphincter (LOS) pressure.
Other causes in infancy and in
older children include: LOS dysfunc-tion (e.g. hiatus hernia); ‘rise’gastric
pressure (e.g. delayed gastric emptying); external gastric pressure; gastric
hypersecretion (e.g. acid); food allergy; and CNS disorders (e.g. cerebral
palsy).
•
Gastrointestinal: regurgitation, non-specific
irritability, rumination, oesophagitis
(heartburn, difficult feeding with crying, painful swallowing, haematemesis),
faltering growth (calorie deficiency due to profuse reflux of ingested
calories).
•
Respiratory: apnoea, hoarseness, cough,
stridor, lower respiratory disease
(aspiration pneumonia, asthma, BPD).
•
Neurobehavioural symptoms: e.g. Sandifer’s syndrome (bizarre
extension and lateral turning of
head, dystonic postures).
· Complications:
•
oesophageal
stricture (dysphagia);
•
barrett’s
oesophagus (premalignant intestinal metaplasia);
•
faltering
growth;
•
anaemia
(chronic blood loss);
•
lower
respiratory disease.
•
History: e.g. effortless regurgitation,
relationship to feeds.
•
Examination: including growth, possible
anaemia, respiratory.
· Investigations
(appropriate when diagnosis is
uncertain, there is a poor response
to treatment, or complications occur) may include: upper GI endoscopy;
oesophageal biopsy; 24hr oesophageal pH probe; barium swallow with fluoroscopy;
radioisotope ‘milk’ scan (aspiration); oesophageal manometry (oesophageal
dysmotility); and CXR (associated respiratory disease).
Treatment is carried out in a
stepwise fashion.
•
Positioning: nurse infants on head-up slope of
30* 9 prone.
•
Dietary: thickened milk feeds (infants);
small frequent meals; avoid food
before sleep; avoid fatty foods, citrus juices, caffeine, carbonated drinks,
‘alcohol and smoking’.
•
Drugs: gastric acid reducing drugs, e.g.
ranitidine or omeprazole (if oesophagitis);
Gaviscon® (contains
antacids and an alginate that forms viscous surface layer to reduce reflux);
prokinetic drugs, e.g. domperidone; mucosal protectors, e.g. sucralfate;
corticosteroids (allergic oesophagitis).
•
Surgery: usually Nissen’s fundoplication is
performed when medical treatment has
failed:
•
Indications
for surgery are failed intense medical treatment; oesophageal stricture;
Barrett’s oesophagus; severe oesophagitis; recurrent apnoea; lower respiratory
disease; faltering growth (FTT).
•
Complications
of surgery include: ‘gas bloating’ syndrome; dysphagia; profuse retching;
‘dumping’ syndrome.
Vast majority of infants outgrow
symptoms by 1yr. In older children, 50% develop a chronic, relapsing course.
This usually occurs in toddlers or
older children with neurological or psychiatric conditions. If the object
reaches the sto-mach 90% will pass spontaneously. Confirm position with AP and
lateral CXR. Remove endoscopically if:
•
Dysphagia
or drooling persists.
•
Object
is still in the oesophagus for >12hr.
•
Object
is sharp (risk of perforation).
•
Object
is hazardous, e.g. mercuric oxide disc batteries.
This disorder is usually due to
diffuse CNS dysfunction.
•
Presentation: choking, cough, drooling,
dysphagia, nasal regurgitation.
•
Diagnosis: barium swallow with
video-fluoroscopy or oesophageal manometry.
•
Treatment: treat primary underlying disorder.
Rarely, cricopharyngeal myotomy is
helpful.
This rare, idiopathic, condition
of obstruction is due to failure of lower oesophageal sphincter relaxation.
•
Presentation: vomiting, dysphagia with solids or
liquids; FTT; aspiration.
•
Diagnosis: barium swallow (dilated tapering
lower oesophagus) or oesophageal
manometry.
•
Treatment: nifedipine (short-term);
endoscopic balloon dilatation; Heller’s
cardiomyotomy.
Causes include severe GORD; caustic ingestion; and radiotherapy.
Treat the underlying cause, e.g.
reduce gastric acid production in GORD; perform balloon endoscopic dilatation.
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