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Is reinnervation of the transplanted heart a concern?
Whether or not significant reinnervation occurs in transplanted human hearts remains to be determined. Laboratory evidence of functional reinnervation exists in non-human cardiac transplantation, and there are some reports supporting sympathetic reinnervation late in the post-transplantation period (>5 years postoperatively) in human patients. However, reinnervation appears to be incomplete in human grafts, and in the first few years following transplantation, there is currently no evidence that reinnervation of transplanted human hearts is a clini-cally important phenomenon.
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