Home | | Microbiology and Immunology | Clinical Syndromes - Human T-Lymphotropic Viruses

Chapter: Microbiology and Immunology: Virology, Virus: Retrovirus

Clinical Syndromes - Human T-Lymphotropic Viruses

HTLV-1 is the causative agent of (a) adult T-cell leukemia (ATL), (b) HTLV-1-associated myelopathy/tropical spastic paraparesis, (c) HTLV-associated uveitis, and (d) HTLV-1-associated infective dermatitis.

Clinical Syndromes

HTLV-1 is the causative agent of (a) adult T-cell leukemia (ATL), (b) HTLV-1-associated myelopathy/tropical spastic paraparesis, (c) HTLV-associated uveitis, and (d) HTLV-1-associated infective dermatitis.

 Adult T-cell leukemia

Adult T-cell leukemia (ATL) is seen in approximately 1 in 20 persons infected by HTLV-1 over a period of 30–50 years. The condition is a malignancy of the CD4 helper T cells, which can be acute or chronic. Acute ATL comprises 55–75% of all the ATL cases. Lymphade-nopathy (both in the periphery and within the body cavities) repre-sents the classic form of ATL. Hepatosplenomegaly, hypercalcemia, and lytic bone lesions are the other manifestations. Death is caused due to opportunistic infections, pulmonary complications, and sepsis. Chronic ATL is a less common manifestation.

 HTLV-1-associated myelopathy/tropical spastic paraparesis

HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a slowly progressing degenerative disease that primarily affects the corticospinal tract of the thoracic spinal cord. The incubation period of HAM/TSP can be as short as 3 months when infection is transmitted by blood transfusion, but is usually 3 years. Patients with HAM/TSP may present with weakness and stiffness in lower limbs, urinary inconti-nence, and lower back pain.

 HTLV-associated uveitis

HTLV-associated uveitis is a less frequent manifestation. The condition is associated with the presence of HTLV-infected lymphocytes in vitreous fluid of the eye.

 HTLV-associated infectious dermatitis

HTLV-associated infectious dermatitis is a chronic and severe form of dermatitis seen during childhood. HTLV-2 has not been associated with any lymphoproliferative disease in humans. It is doubtful that HTLV types 3 and 4 cause any human disease.

Study Material, Lecturing Notes, Assignment, Reference, Wiki description explanation, brief detail
Microbiology and Immunology: Virology, Virus: Retrovirus : Clinical Syndromes - Human T-Lymphotropic Viruses |


Privacy Policy, Terms and Conditions, DMCA Policy and Compliant

Copyright © 2018-2023 BrainKart.com; All Rights Reserved. Developed by Therithal info, Chennai.