Buffalopox, believed to be caused by vaccinia virus, occurs among buffaloes in India. In the infected buffaloes, the viruses produce pustular lesions on the teats and udders of lactating buffaloes. The individuals, such as milkmen, coming in con-tact with these infected buffaloes suffer from the infection. The lesions usually develop on the hands and faces of the milkmen.
Buffalopox appears to be distinct from variola and vaccinia viruses. Smallpox vaccine does not confer protection against infection by buffalopox.