Antimicrobics
Acting on the Outer and Cytoplasmic Membranes
The polypeptide antimicrobics polymyxin B and colistin
have a cationic detergent-like effect. They bind to the cell membranes of
susceptible Gram-negative bacteria and alter their permeability, resulting in
loss of essential cytoplasmic components and bacterial death. These agents
react to a lesser extent with cell membranes of the host, resulting in
nephrotoxicity and neurotoxicity. Their spectrum is essentially Gram-negative;
they act against P. aeruginosa and
other Gram-negative rods. Although these antimicrobics were used for systemic
treatment in the past, their use is now limited to topical applications. They
have an advantage; resistance to them rarely develops.
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