BARTONELLA
Bartonella species differ from rickettsiae
in that they can be cultured on artificial media.By 16s ribosomal comparison
they are actually more closely related to Brucella
than to rickettsiae. Bartonella quintana,
the best known species of this genus, causes trenchfever, which has a worldwide distribution. The name derives
from its prominence in thetrenches of World War I. This disease has a reservoir
in humans, and its vector is the body louse. Most cases are mild or
subclinical. When symptomatic, the patient has sudden on-set of chills,
headache, relapsing fever, and a maculopapular rash on the trunk and ab-domen.
Illness can last for 14 to 30 days and the disease is suggested by a history of
louse contact. More recently, B. quintana
bacteremia and endocarditis have been described in homeless alcoholic men in
both France and the United States. The diagnosis can be made by culturing the
organism on special agar medium or by demonstrating seroconversion.
Bartonella bacilliformis, a related organism, is the cause
of acute Oroya fever and, inits chronic phase, verruga peruana. Infections with
this agent are seen only in South America at intermediate altitudes, in keeping
with the distribution of its sandfly vector.
Another species, Bartonella
henselae, has been associated with a number of diseases, the most common of
which is cat scratch disease. Cat
scratch disease is a febrile lym-phadenitis with systemic symptomatology that
sometimes persists for weeks to months. Approximately 24,000 cases occur in the
United States each year. The disease is thought to be transmitted by cat
scratches or bites and perhaps by the bites of cat fleas. Manifesta-tions may
include skin rashes, conjunctivitis, encephalitis, and prolonged fever.
Occasion-ally, retinitis, endocarditis, and granulomatous or suppurative
hepatosplenic and osseous lesions have also been seen. B. henselae has been isolated directly from the blood of cats,
although the latter do not appear ill. It can also be isolated from human
blood, lymph nodes, and other materials using special media. Organisms can
sometimes be directly demonstrated in infected tissues by using the
Warthin–Starry silver impregnation stain. A serologic response to B. henselae antigens is the primary
method of diagnosis. Azithromycin or erythromycin may reduce the duration of
lymph node enlargement and symptoms.
Bacillary angiomatosis, a proliferative disease of
small blood vessels of the skin and viscera, seen in acquired immunodeficiency
syndrome (AIDS) patients and other im-munocompromised hosts, has been
associated with Bartonella by
molecular methods. The PCR was used to
amplify ribosomal RNA gene fragments directly from tissue samples. Sequence
analysis of DNA transcribed from these fragments pointed to the Bartonella genus. Subsequently, both B. henselae and B. quintana have been iso-lated from AIDS patients with bacillary
angiomatosis. Other conditions seen primarily in AIDS patients, such as
peliosis hepatis and bacteremia with fever, have also been associ-ated with B. henselae. Bartonella infections in
AIDS and other immunosuppressed patients, as well as the bacteremia observed in
alcoholic and homeless men, generally respond to prolonged courses of
erythromycin. Bartonella endocarditis
usually requires valve replacement as well.
Related Topics
Privacy Policy, Terms and Conditions, DMCA Policy and Compliant
Copyright © 2018-2024 BrainKart.com; All Rights Reserved. Developed by Therithal info, Chennai.