Alcohol Withdrawal
Alcohol withdrawal is a condition that follows a
reduction in al-cohol consumption or an abrupt cessation of drinking in
alcohol-dependent individuals. In addition to significant distress, alcohol
withdrawal is also associated with impairment of social, occu-pational and
other areas of functioning. Uncomplicated cases of alcohol withdrawal are
characterized by signs and symptoms of autonomic hyperactivity, and may include
increased heart rate, increased blood pressure, hyperthermia, diaphoresis,
tremor, nausea, vomiting, insomnia and anxiety. Onset of symptoms of
uncomplicated alcohol withdrawal usually occurs between 4 and 12 hours
following the last drink. Symptom severity tends to peak around the second day,
usually subsiding by the fourth or fifth day of abstinence. After this period,
less severe anxiety, insomnia and autonomic symptoms may persist for a few
weeks, with some individuals experiencing a protracted alcohol-withdrawal
syn-drome up to 5 or 6 months after cessation of drinking. A small but
significant number of alcohol-dependent individuals (10%) can experience
complicated alcohol-withdrawal episodes. Alcohol-withdrawal delirium (also
known as delirium tremens) can occur in 5% of the cases, usually between 36 and
72 hours following alcohol cessation. In addition to signs of autonomic
hyperactivity, this condition is characterized by illusions, auditory, visual,
or tactile hallucinations, psychomotor agitation, fluctuating cloudi-ness of
consciousness and disorientation. Grand-mal seizures associated with
alcohol-withdrawal occur in 3 to 5% of the cases, typically within the first 48
hours following reduction or cessation of drinking. In both instances of
complicated alcohol withdrawal, lack or delay in instituting proper treatment
is associated with an increased mortality rate. Prior history of delirium
tremens and/or alcohol-withdrawal seizures, older age, poor nutritional status,
comorbid medical conditions and history of high tolerance to al-cohol are
predictors of increased severity of alcohol withdrawal.
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