Chapter: Clinical Cases in Anesthesia : Coronary Artery Bypass Grafting

What are the major determinants of myocardial oxygen supply and demand?

The major determinants of myocardial oxygen supply include:

What are the major determinants of myocardial oxygen supply and demand?

The major determinants of myocardial oxygen supply include:

· Coronary anatomy

· Diastolic filling time↑

· Aortic diastolic pressure (ADP)↑

· Left ventricular end-diastolic pressure (LVEDP)↓

· Coronary perfusion pressure↑ (CPP).

CPP = ADP – LVEDP

The major determinants of myocardial oxygen demand in decreasing order include:

· Left ventricular wall tension

Tension = (pressure × radius)/2 × wall thickness

· Heart rate

· Contractility

· Afterload.

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Clinical Cases in Anesthesia : Coronary Artery Bypass Grafting : What are the major determinants of myocardial oxygen supply and demand? |