The two major uricosurics are:
Uricosurics act by increasing uric acid excretion in urine. The pri-mary goal in using uricosurics is to prevent or control the frequen-cy of gouty arthritis attacks.
Uricosurics are absorbed from the GI tract.
Distribution of the two drugs is similar, with 75% to 95% of probenecid and 98% of sulfinpyrazone being protein-bound.
Metabolism of the drugs occurs in the liver, and excretion is pri-marily by the kidneys. Only small amounts of these drugs are ex-creted in stool.
Probenecid and sulfinpyrazone reduce the reabsorption of uric acid at the proximal convoluted tubules of the kidneys. This re-sults in excretion of uric acid in urine, reducing serum urate lev-els.
Probenecid and sulfinpyrazone are indicated for the treatment of :
· chronic gouty arthritis
· tophaceous gout (the deposition of tophi or urate crystals under the skin and into joints).
Probenecid is also used to promote uric acid excretion in patients experiencing hyperuricemia.
Probenecid and sulfinpyrazone shouldn’t be given during an acute gouty attack. If taken at that time, these drugs prolong inflamma-tion. Because these drugs may increase the chance of an acute gouty attack when therapy begins and whenever the serum urate level changes rapidly, colchicine is administered during the first 3 to 6 months of probenecid or sulfinpyrazone therapy.
Many drug interactions, some potentially serious, can occur with uricosuric drugs:
§ Probenecid significantly increases or prolongs the effects of cephalosporins, penicillins, and sulfonamides.
§ Serum urate levels may increase when probenecid is taken with antineoplastic drugs.
§ Probenecid increases the serum concentration of dapsone, aminosalicylic acid, and methotrexate, causing toxic reactions.
§ Sulfinpyrazone increases the effectiveness of warfarin, increas-ing the risk of bleeding.
§ Salicylates reduce the effects of sulfinpyrazone.
§ Sulfinpyrazone may potentiate the effects of oral antidiabetic drugs, increasing the risk of hypoglycemia. (See Adverse reac-tions to uricosurics.)