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Chapter: Pathology: Joint Pathology

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Seronegative Spondyloarthropathies

Reactive arthritis is characterized by a classic triad of conjunctivitis, urethritis, and arthritis.

SERONEGATIVE SPONDYLOARTHROPATHIES

 

 

Seronegative spondyloarthropathies are a group of disorders characterized by the following:

 

         Rheumatoid factor seronegativity

 

         Involvement of the sacroiliac joints

 

         Association with HLA-B27

 

Ankylosing spondylitis occurs predominantly in young men with HLA-B27 (90% of cases); usually involves the sacroiliac joints and spine; and may be associated with inflammatory bowel disease.


Reactive arthritis is characterized by a classic triad of conjunctivitis, urethritis, and arthritis. The arthritis affects the ankles and knees. It affects males more than females, with onset age 20s–30s. Onset often follows a venereal disease or bacillary dysentery.

 

Enteropathic arthritis occurs in 10–20% of patients with inflammatory bowel disease.

 

Psoriatic arthritis affects 5–10% of patients with psoriasis; is often a mild and slowly progressive arthritis, with pathology similar to RA..


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