Probucol is rarely used as a hypolipidaemic agent because of its unreliability in lowering LDL levels, and also because of its tendency to persistently lower HDL levels. However it is remarkably efficacious in lowering cholesterol levels in patients with homozygous familial hypercholesterolaemia.
Adverse effects include flatulence, nausea, diarrhoea, headache, vertigo. Diarrhoea can be minimised or prevented by combining with cholestyramine.
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