Chapter: Modern Medical Toxicology: Cardiovascular Poisons: Cardiac Drugs and Lipid Lowering Agents

Probucol - Cardiovascular Poisons

Probucol is rarely used as a hypolipidaemic agent because of its unreliability in lowering LDL levels, and also because of its tendency to persistently lower HDL levels.

PROBUCOL

Probucol is rarely used as a hypolipidaemic agent because of its unreliability in lowering LDL levels, and also because of its tendency to persistently lower HDL levels. However it is remarkably efficacious in lowering cholesterol levels in patients with homozygous familial hypercholesterolaemia.

Adverse effects include flatulence, nausea, diarrhoea, headache, vertigo. Diarrhoea can be minimised or prevented by combining with cholestyramine.

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Modern Medical Toxicology: Cardiovascular Poisons: Cardiac Drugs and Lipid Lowering Agents : Probucol - Cardiovascular Poisons |