TOPICAL ANTIFUNGAL AGENTS
Ciclopirox olamine (Loprox) is a pyridone derivative
available for the treatment of cutaneous dermatophyte infections, cutaneous C. albicans infections, and tinea
versicolor caused by Malassezia furfur.
It interferes with fungal growth by inhibiting macromolecule synthesis.
Tolnaftate (Tinactin, others) is a nonprescription
an-tifungal agent effective in the topical treatment of der-matophyte
infections and tinea. The mechanism of ac-tion is unknown.
Other older, less effective
topical antifungal agents still available include undecylenic acid (Desenex, oth-ers). Used in the treatment
of topical dermatophytes, undecylenic acid is fungistatic, requires prolonged
ad-ministration, and is associated with a high relapse rate. Desenex, containing 5% undecylenic acid
and 20% zinc undecylenate, is
effective in the prevention of recurrent tinea pedis.