Clotrimazole (Lotrimin, Gyne-Lotrimin, Mycelex) is a
broad-spectrum fungistatic imidazole drug used in the topical treatment of
oral, skin, and vaginal infections with C.
albicans. It is also employed in the treatment of infections with cutaneous
Topical use results in
therapeutic drug concentra-tions in the epidermis and mucous membranes; less
than 10% of the drug is systemically absorbed. Al-though clotrimazole is
generally well tolerated, local ab-dominal cramping, increased urination, and
transient liver enzyme elevations have been reported.