Inguinal lymphadenitis may be seen with several STDs,
especially primary herpes sim-plex infection and lymphogranuloma venereum. The
latter is caused by specific strains of C.
trachomatis. It may begin as a small genital ulcer, which is frequently
unnoticed. Moreoften, the first evidence of lymphogranuloma venereum is a
tender swollen inguinal lym-phadenitis, which may suppurate and drain
spontaneously if not treated. Primary syphilismay be associated with unilateral
or bilateral inguinal lymph node enlargement, but these nodes are not usually
tender. Secondary syphilis may be associated with generalized lym-phadenopathy.