Blood Clotting: Prothrombin time and other
bloodclotting parameters are likely to be abnormal in acute poisoning with
hepatotoxic agents, rodenticides containinganticoagulants, as well as in
certain types of snake bite, (especially viper).
Haematocrit: Acute overdose involving iron
salts,NSAIDs, and salicylates can cause gastrointestinal bleeding leading to
anaemia. Anaemia may also result from chronic exposure to heavy metals such as
arsenic and lead. A less common (indirect) cause is glucose-6-phosphate dehy-drogenase deficiency when any of the
following drugshave been administered : chloramphenicol, chloroquine,
nitrofurantoin, primaquine, etc.
Leucocyte Count: Leucocytosis is a recognised
featureof acute metabolic acidosis resulting from ingestion of poisons such as
ethylene glycol and methanol. It is also seen as a secondary feature of
hypostatic pneumonia following prolonged coma.