Chapter: Modern Medical Toxicology: Analytical Toxicology: Biochemical and Haematological Tests

Haematological Tests - Analytical Toxicology

Blood Clotting: Prothrombin time and other bloodclotting parameters are likely to be abnormal in acute poisoning with hepatotoxic agents, rodenticides containinganticoagulants, as well as in certain types of snake bite, (especially viper).

HAEMATOLOGICAL TESTS

· Blood Clotting: Prothrombin time and other bloodclotting parameters are likely to be abnormal in acute poisoning with hepatotoxic agents, rodenticides containinganticoagulants, as well as in certain types of snake bite, (especially viper).

· Haematocrit: Acute overdose involving iron salts,NSAIDs, and salicylates can cause gastrointestinal bleeding leading to anaemia. Anaemia may also result from chronic exposure to heavy metals such as arsenic and lead. A less common (indirect) cause is glucose-6-phosphate dehy-drogenase deficiency when any of the following drugshave been administered : chloramphenicol, chloroquine, nitrofurantoin, primaquine, etc.

· Leucocyte Count: Leucocytosis is a recognised featureof acute metabolic acidosis resulting from ingestion of poisons such as ethylene glycol and methanol. It is also seen as a secondary feature of hypostatic pneumonia following prolonged coma.

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Modern Medical Toxicology: Analytical Toxicology: Biochemical and Haematological Tests : Haematological Tests - Analytical Toxicology |