Discuss the sequence of clinical anesthesia following neural blockade

Discuss the sequence of clinical anesthesia following neural blockade.

Nerve fibers are classified according to their fiber diam-eter, whether they are myelinated or unmyelinated, and their function. Generally, the small-diameter fibers are more easily blocked than large-diameter fibers. However, larger myelinated fibers are more readily blocked than the smaller unmyelinated fibers. Preganglionic B fibers are more readily blocked than any fiber, even though their fibers are larger than the smallest type C, presumably because of the presence of myelin. Thus, sympathetic blockade with peripheral vasodilation and skin temperature elevation occurs first following neural blockade. This is sequentially followed by loss of pain and temperature sensation, loss of proprioception, loss of touch and pressure sensation, and finally motor paralysis (largest myelinated A-α fibers).