Biosynthesis of Complement
Various components of the complement are synthesized at vari-ous sites of the body. For example, C1 is synthesized in the intes-tinal epithelium, both C2 and C4 in the macrophages, C5 and C8 in the spleen, and C3, C6, and C9 in the liver. There is an increase in the level of C3, C4, C5, and C6 in the acute phase of inflam-mation. Complement along with some other plasma proteins known as acute phase reactants show a rise in acute inflammation.