A few drugs are available for therapy of systemic fungal infection, unlike a large number of antibiotics available to treat bacterial infections. The drugs used to treat bacterial disease have no effect on fungal diseases. Amphotericin B and various azoles are the most effective antifungal drugs. They act on the ergosterol of fungal cell membrane that is not found in bacterial or human cell membrane. Similarly, caspo-fungin inhibits synthesis of beta-glucan, which is found only in fungal membrane but not in bacterial or human cell mem-brane. Table 71-3 summarizes the common antifungal agents and their primary sites of activity.