Anticonvulsant drugs inhibit neuromuscular transmission and areprescribed for:
· long-term management of chronic epilepsy (recurrent seizures)
· short-term management of acute isolated seizures not caused by epilepsy, such as those occurring after trauma or brain surgery.
· In addition, some anticonvulsants are used in the emergency treatment of status epilepticus (a continuous seizure state).
· Treatment of epilepsy should begin with a single drug whose dosage is increased until seizures are controlled or adverse reac-tions become problematic. Generally, a second alternative should be tried as monotherapy before combination therapy is consid-ered. The choice of drug treatment depends on seizure type, drug characteristics, and patient preferences.
Anticonvulsants fall into several major classes:
· carboxylic acid derivatives
· 1-(aminomethyl) cyclohexane–acetic acid
· sulfamate-substituted monosaccharides