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Chapter: Clinical Pharmacology: Neurologic and neuromuscular drugs

Anticonvulsant drugs

Anticonvulsant drugs inhibit neuromuscular transmission and areprescribed for: · long-term management of chronic epilepsy (recurrent seizures)

Anticonvulsant drugs

Anticonvulsant drugs inhibit neuromuscular transmission and areprescribed for:

 

·                 long-term management of chronic epilepsy (recurrent seizures)

·                 short-term management of acute isolated seizures not caused by epilepsy, such as those occurring after trauma or brain surgery.

·                 In addition, some anticonvulsants are used in the emergency treatment of status epilepticus (a continuous seizure state).

·                 Treatment of epilepsy should begin with a single drug whose dosage is increased until seizures are controlled or adverse reac-tions become problematic. Generally, a second alternative should be tried as monotherapy before combination therapy is consid-ered. The choice of drug treatment depends on seizure type, drug characteristics, and patient preferences.


Major classes


Anticonvulsants fall into several major classes:

 

·                 Hydantoins

 

·                 barbiturates

 

·                 iminostilbenes

 

·                 benzodiazepines

 

·                 carboxylic acid derivatives

 

·                 1-(aminomethyl) cyclohexane–acetic acid

 

·                 phenyltriazines

 

·                 carboxamides

 

·                 sulfamate-substituted monosaccharides

 

·                 succinimides

 

·                 sulphonamides

 

·                 pyrrolidines.

 

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Clinical Pharmacology: Neurologic and neuromuscular drugs : Anticonvulsant drugs |


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