What is the onset of action for acetylcholinesterase inhibitors?

What is the onset of action for acetylcholinesterase inhibitors?

When single twitch height exceeds 20% of control, neu-romuscular blockade can be quickly antagonized by acetyl-cholinesterase inhibitors. Greater degrees of twitch height depression require more time, occasionally as much as 30–40 minutes. When twitches are absent on TOF stimula-tion, anticholinesterase therapy generally results in partial paralysis and unsafe extubation conditions.