What are the physiologic effects of glucocorticosteroids?
Glucocorticosteroids are produced by the
adrenal glands in response to stimulation by adrenocorticotropic hormone
(ACTH). ACTH is secreted by the pituitary in response to
corticotropin-releasing hormone (CRH), which is pro-duced in the hypothalamus.
Glucocorticosteroids primarily affect intermediary metabolism.
Glucocorticosteroids dif-fuse through the cell membrane and bind to specific
gluco-corticosteroid receptors, creating a complex that migrates to the nucleus
and alters gene transcription. Resulting physio-logic effects include a rise in
the blood glucose, mobilization of fatty acids, catabolism, and