Recommendation for the Treatment of Latent Tuberculosis Infection

RECOMMENDATION FOR THE TREATMENT OF LATENT TUBERCULOSIS INFECTION

Recently revised recommendations for the treatment of latent tuberculosis infection (LTBI) include new thera-peutic regimens as follows:

Isoniazid for 9 months daily or twice weekly is preferred for all adults.

Or

Isoniazid for 6 months daily or twice weekly is ac-ceptable for HIV-negative patients and is cost effective.

Or

Rifampin and pyrazinamide daily for 2 months is appropriate for isoniazid-resistant tuberculosis.

Or

Rifampin daily for 4 months may be given to indi-viduals who cannot tolerate pyrazinamide.