INFLAMMATORY MYOPATHIES
Polymyositis is an autoimmune disease seen in adults. It
presents with bilateral proximal muscle weakness.
Microscopic exam demonstrates endomysial lympho-cytic inflammation (mostly
cytotoxic T8) and skeletal muscle fiber degeneration and regeneration. Patients
respond to immunosuppression.
Dermatomyositis is a connective tissue
disorder involving inflammation of skeletal muscle and skin. It can
affect both children and adults. It presents with bilateral proximal muscle weakness,
skin rash of the upper eyelids, and periorbital edema.
Microscopic exam demonstrates
perimysial and vascular lymphocytic inflamma-tion, perifascicular fiber
atrophy, and skeletal muscle fiber degeneration and regen-eration. Adult
patients are at increased risk of lung, colon, breast, and gynecologic cancers.
Inclusion body myositis affects adults age >50,
causing slowly progressive, asym-metrical, distal muscle weakness. Light
microscopy demonstrates autophagic vacu-oles and inclusion bodies in addition
to inflammation and necrosis. The disease is refractory to immunosuppressive
therapy.
Related Topics
Privacy Policy, Terms and Conditions, DMCA Policy and Compliant
Copyright © 2018-2024 BrainKart.com; All Rights Reserved. Developed by Therithal info, Chennai.