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EFFECTS OF DRUG ON BODY
Here we come across with Pharmacokinetics and Pharmacodynamics of the drug.
Pharmacokinetics – It describes the movement of the drug in our body, about its absorption, distribution, metabolism and excretion.
Pharmacodynamics – It describes about the mechanism of action of a drug at cellular, sub-cellular, and at molecular levels. The important principles of mechanism of action are stimulation, depression, replacement, irritation and cytotoxic action.
Side effects: are the unwanted but often unavoidable consequences of administered drug. E.g., aspirin produces gastric ulcer.
Toxic effects: they are due to over dosage or prolonged use. e.g., paracetamol causes hepatotoxicity..
Teratogenicity: it refers to the capacity of a drug to cause foetal abnormalities when administered to a pregnant mother. E.g., Tetracycline
Idiosyncrasy: it is a genetically determined abnormal reaction to a drug in an unusual manner. E.g., barbiturates.
Drug dependence: drugs capable of altering mood and feelings on repeated use of such drugs. E.g., morphine
Iatrogenic disease: this a physician induced or drug induced disease. E.g., peptic ulcer by salicylates.
Drug allergy: it is an immunologically mediated unpredictable reactions which are not related to the therapeutic effects.
Carcinogenicity and Mutagenicity: it is the capacity of a drug to cause cancer. e.g., anabolic steroids.
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