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Chapter: Pathology: Amyloidosis

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Composition of Amyloid

Amyloidosis is a group of diseases characterized by the deposition of an extracellular protein that has specific properties.

COMPOSITION OF AMYLOID

Amyloidosis is a group of diseases characterized by the deposition of an extracellular protein that has specific properties.

·            Individual molecular subunits form β-pleated sheets. Amorphous eosinophilic extracellular deposits of amyloid are seen on the H&E stain. These deposits stain red with the Congo red stain, and apple green birefringence of the amy-loid is seen on the Congo red stain under polarized light.

 

·            The fibrillary protein of amyloid varies with each disease. Also present in amy-loid are serum amyloid P (SAP) and glycosaminoglycans (heparan sulfate).

 

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