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Chapter: Pathology: Hematopoetic Pathology–White Blood Cell Disorders & Lymphoid and Myeloid Neoplasms

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B and T Lymphoblastic Lymphoma/Leukemia

Acute Lymphoblastic Leukemia (ALL), Lymphoblastic Lymphoma.

B AND T LYMPHOBLASTIC LYMPHOMA/LEUKEMIA

 

Acute Lymphoblastic Leukemia (ALL)

 

Karyotypic abnormalities: Most pre-B-cell tumors are hyperdiploid. Translo-cations are common in both B-ALL and T-ALL.

Immunophenotyping. Most tumors are positive for terminal deoxytransferase (TdT).

 

         B-cell lineage classification is based on presence or absence of cytoplas-mic or surface markers, including surface immunoglobulin (sIg) pres-ence (mature B-ALL) and cytoplasmic μ presence (pre-BALL). The B-cell tumors almost always express B-cell molecules CD19 and CD10.

 

         T-cell lineage: The majority of T-ALLs stain with CD2, CD3, CD5, and CD7.

 

B-ALL is more common in children; symptoms include fever, anemia, and bleeding

 

T-ALL often presents as a mediastinal mass in an adolescent male

 

Lymphoblastic Lymphoma

 

Most cases of lymphoblastic lymphoma are T-cell neoplasms that are aggressive and rapidly progressive. Most patients are young males with a mediastinal mass (think thymus). The leukemic phase of lymphoblastic lymphoma is similar to T-ALL and some consider them the same entity. Most cells are CD1+, CD2+, CD5+, and CD7+.

 

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