Alkalinizing and acidifying drugs
Alkalinizing and acidifying drugs act to correct acid-base imbal-ances in the blood. These acid-base imbalances include:
· metabolic acidosis, a decreased serum pH caused by excess hy-drogen ions in the ECF, which is treated with alkalinizing drugs
· metabolic alkalosis, an increased serum pH caused by excessbicarbonate in the ECF, which is treated with acidifying drugs.
Alkalinizing and acidifying drugs have opposite effects:
§ An alkalinizing drug will increase the pH of the blood and de-crease the concentration of hydrogen ions.
§ An acidifying drug will decrease the pH of the blood and in-crease the concentration of hydrogen ions.
Some of these drugs also alter urine pH, making them useful in treating some urinary tract infections and drug overdoses.