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Chapter: Modern Pharmacology with Clinical Applications: Drugs Used in Tuberculosis and Leprosy

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Recommendation for the Treatment of Latent Tuberculosis Infection

Recently revised recommendations for the treatment of latent tuberculosis infection (LTBI) include new thera-peutic regimens as follows:

RECOMMENDATION FOR THE TREATMENT OF LATENT TUBERCULOSIS INFECTION

 

Recently revised recommendations for the treatment of latent tuberculosis infection (LTBI) include new thera-peutic regimens as follows:

 

Isoniazid for 9 months daily or twice weekly is preferred for all adults.

 

Or

 

Isoniazid for 6 months daily or twice weekly is ac-ceptable for HIV-negative patients and is cost effective.

 

Or

 

Rifampin and pyrazinamide daily for 2 months is appropriate for isoniazid-resistant tuberculosis.

 

Or

 

Rifampin daily for 4 months may be given to indi-viduals who cannot tolerate pyrazinamide.

 

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