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Chapter: Clinical Cases in Anesthesia : Mitral Stenosis

What is the etiology and pathophysiology of mitral stenosis?

Mitral stenosis is frequently rheumatic in origin. In many patients, there is a latency period of 30–40 years between the episode of rheumatic fever and the onset of clinical symptoms.

What is the etiology and pathophysiology of mitral stenosis?

 

Mitral stenosis is frequently rheumatic in origin. In many patients, there is a latency period of 30–40 years between the episode of rheumatic fever and the onset of clinical symptoms. Dyspnea is the most common symp-tom. The initial presentation is often due to an episode of atrial fibrillation or to an unrelated condition, such as preg-nancy, thyrotoxicosis, anemia, or sepsis. Other common symptoms include fatigue, palpitations, or hemoptysis.

 

In the normal adult, the mitral valve orifice is 4–6 cm2. As the orifice narrows, to less than 2 cm2, the pressure gradient between the left atrium and left ventricle must increase to maintain adequate flow. The high left atrial pressure causes pulmonary venous congestion, which eventually leads to pulmonary edema, particularly in the presence of tachycardia (Figure 6.1). Tachycardia shortens diastole and diminishes the time available for flow across the mitral valve. This, in turn, impairs left atrial emptying and left ventricular filling. Cardiac output decreases, pulmonary congestion increases, and decompensation ensues. A mitral valve area less than 1.0 cm2 is considered critical. The decision to perform valve surgery, however, is usually based on the severity of symp-toms (i.e., New York Heart Association Classification).




Although the left ventricle is “protected” from pressure or volume overload, left ventricular contractility may be impaired by rheumatic involvement of the papillary muscles and mitral annulus. Left ventricular function might also be impaired by a shift of the interventricular septum due to right ventricular (RV) pressure overload. Pulmonary hyper-tension and RV failure are often observed in mitral stenosis.

 

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Clinical Cases in Anesthesia : Mitral Stenosis : What is the etiology and pathophysiology of mitral stenosis? |


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