How is thyroid hormone regulated?

How is thyroid hormone regulated?

The hypothalamus secretes thyrotropin-releasing hor-mone (TRH), which stimulates the release of thyroid-stimulating hormone (TSH) by the anterior pituitary gland. The thyroid gland, in response to TSH, releases T₃ and T₄ into the circulation. TSH also causes increased uptake of iodide and increased iodination of thyroglobu-lin. Both T₃ and T₄ have a negative-feedback effect on the hypothalamus and pituitary glands.