HODGKIN LYMPHOMA
Hodgkin lymphoma has some characteristics
that are different from non-Hodgkin lymphoma.
•
May present similar to infection (with fever)
•
Spread is contiguous to adjacent node groups
•
No leukemic state
•
Extranodal spread is uncommon
The malignant cells are the
diagnostic Reed-Sternberg cells; these malignant cells are intermixed with
reactive inflammatory cells. The Reed-Sternberg cell is a large malignant tumor
cell that has a bilobed nucleus with a prominent large inclusion-like nucleolus
in each lobe.
Hodgkin lymphoma
classification:
•
Lymphocyte-rich
type
(rare): composed primarily of reactive lymphocytes;
associated
with Epstein-Barr virus (40% of cases)
•
Lymphocyte-predominant
type: has lymphohistocytic variants (L&H cells, called “popcorn cells”) and a unique
phenotype (CD45+, CD15-, CD30-, CD20+)
•
Mixed
cellularity type:
occurs in middle-aged and older males; the increased
number
of eosinophils is related to IL-5 secretion
•
Lymphocyte-depleted
type:
presents with abdominal adenopathy; Reed-Stern-berg cells predominate
•
Nodular
sclerosis type
(most common subtype (65–70% of cases)): is only type in which females > males
°° Lymph node has broad
collagen bands
°° Reed-Sternberg cell
has clear space in the cytoplasm (lacunar cell)
Hodgkin lymphoma has
a bimodal age group distribution (age late 20s and >50).
Patients usually
present with painless enlargement of lymph nodes.
Poor prognosis is
directly proportional to the number of Reed-Sternberg cells pres-ent. Survivors
of chemotherapy and radiotherapy have increased risk for secondary non-Hodgkin
lymphoma or acute leukemia.
Related Topics
Privacy Policy, Terms and Conditions, DMCA Policy and Compliant
Copyright © 2018-2024 BrainKart.com; All Rights Reserved. Developed by Therithal info, Chennai.