The form in which a drug is manufactured and the way in which the parent dispenses the drug to the child determine the actual dose administered.....
Physiologic processes that influence pharmacokinetic variables in the infant change significantly in the first year of life, particularly during the f....
Most drugs taken by pregnant women can cross the placenta and expose the developing embryo and fetus to their pharmacologic and teratogenic effects.....
Although it has been largely replaced by inhaled β agonists, theo-phylline continues to be used for the treatment of bronchospasm by some patients wi....
In the USA, rattlesnakes are the most common venomous reptiles. Bites are rarely fatal, and 20% do not involve envenomation. ....
Ethylene glycol and methanol are alcohols that are important toxins because of their metabolism to highly toxic organic acids .....
Overdosage with ethanol and sedative-hypnotic drugs (eg, benzo-diazepines, barbiturates, γ-hydroxybutyrate [GHB], carisoprodol [Soma];) occurs freque....
Digitalis and other cardiac glycosides and cardenolides are found in many plants and in the skin of some toads.....
Cyanide (CN−) salts and hydrogen cyanide (HCN) are highly toxic chemicals used in chemical synthesis, as rodenticides (eg, “gopher getter”), for....
Organophosphate and carbamate cholinesterase inhibitors are widely used to kill insects and other pests.....
Calcium antagonists can cause serious toxicity or death with rela-tively small overdoses.....
In overdose, β blockers inhibit both β1 and β2 adrenoceptors; selectivity, if any, is lost at high dosage.....
Salicylate poisoning is a much less common cause of childhood poisoning deaths since the introduction of child-resistant containers and the reduced u....
Antipsychotic drugs include the older phenothiazines and butyro-phenones, as well as newer atypical drugs. ....
Tricyclic antidepressants (eg, amitriptyline, desipramine, doxe-pin, many others;) are among the most common prescription drugs involved in life-threa....
A large number of prescription and nonprescription drugs, as well as a variety of plants and mushrooms, can inhibit the effects of acetylcholine at mu....
At the doses usually used by stimulant abusers, euphoria and wakefulness are accompanied by a sense of power and well-being. ....
Acetaminophen is one of the drugs commonly involved in suicide attempts and accidental poisonings, both as the sole agent and in combination with othe....