Home | | Pharmaceutical Biotechnology: Fundamentals and Applications | Adalimumab - Arthritides - Monoclonal Antibodies in Anti inflammatory Therapy

Chapter: Pharmaceutical Biotechnology: Fundamentals and Applications - Monoclonal Antibodies in Anti inflammatory Therapy

| Study Material, Lecturing Notes, Assignment, Reference, Wiki description explanation, brief detail |

Adalimumab - Arthritides - Monoclonal Antibodies in Anti inflammatory Therapy

Adalimumab is a recombinant human IgG1 mono-clonal antibody to TNF-a that specifically blocks receptor binding of TNF-a (but not TNF-b);

Adalimumab

 

Adalimumab is a recombinant human IgG1 mono-clonal antibody to TNF-a that specifically blocks receptor binding of TNF-a (but not TNF-b); it also lyses cells expressing TNF-a on their surface in the presence of complement proteins. Adalimumab is currently FDA approved for use in patients with RA, PsA, and AS as a 40 mg dose SC every other week. It may be used in combination with glucocorticoids, salicylates, non-steroidal anti-inflammatory drugs (NSAIDs), analgesics, methotrexate or other DMARDs. In addition, an increased dosing frequency of 40 mg SC every week is on label for RA patients not receiving methotrexate in combination with adalimu-mab (package insert for Humira, 2006).

 

Study Material, Lecturing Notes, Assignment, Reference, Wiki description explanation, brief detail


Copyright © 2018-2020 BrainKart.com; All Rights Reserved. Developed by Therithal info, Chennai.