AUTOIMMUNE (TYPE II) REACTIONS TO
DRUGS
Certain autoimmune
syndromes can be induced by drugs. Examples include systemic lupus
erythematosus following hydral-azine or procainamide therapy, “lupoid
hepatitis” due to cathartic sensitivity, autoimmune hemolytic anemia resulting
from methyl-dopa administration, thrombocytopenic purpura due to quini-dine,
and agranulocytosis due to a variety of drugs. As indicated, a number of drugs
are associated with type I and type II reactions. In these drug-induced
autoim-mune states, IgG antibodies bind to drug-modified tissue and are
destroyed by the complement system or by phagocytic cells with Fc receptors.
Fortunately, autoimmune reactions to drugs usually subside within several
months after the offending drug is with-drawn. Immunosuppressive therapy is
warranted only when the autoimmune response is unusually severe.
Related Topics
Privacy Policy, Terms and Conditions, DMCA Policy and Compliant
Copyright © 2018-2024 BrainKart.com; All Rights Reserved. Developed by Therithal info, Chennai.