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Chapter: Clinical Cases in Anesthesia : Pheochromocytoma

What is a pheochromocytoma?

Preganglionic sympathetic fibers synapse in the adrenal medulla.

What is a pheochromocytoma?

 

Preganglionic sympathetic fibers synapse in the adrenal medulla. Under normal circumstances, this neuroendocrine tissue produces approximately 80% epinephrine and 20% norepinephrine, which function as hormones instead of neurotransmitters.

 

Most pheochromocytomas are adrenal medullary tumors, although a small percentage appear in the spleen, ovary, bladder, and right atrium. They usually arise from chromaffin cells, although 6% arise from other neuro-endocrine tissue. These tumors usually secrete more nor-epinephrine than epinephrine, similar to the normal tissue. Infrequently, pheochromocytomas secrete predominantly epinephrine or dopamine. They may occur independently or as part of a multiple endocrine neoplastic (MEN) syndrome .

 

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Clinical Cases in Anesthesia : Pheochromocytoma : What is a pheochromocytoma? |


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