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Chapter: Basic & Clinical Pharmacology : Management of the Poisoned Patient

Toxic Syndromes: Antipsychotics

Antipsychotic drugs include the older phenothiazines and butyro-phenones, as well as newer atypical drugs.

ANTIPSYCHOTICS

Antipsychotic drugs include the older phenothiazines and butyro-phenones, as well as newer atypical drugs. All of these can cause CNS depression, seizures, and hypotension. Some can cause QT prolongation. The potent dopamine D2 blockers are also associ-ated with parkinsonian movement disorders (dystonic reactions) and in rare cases with the neuroleptic malignant syndrome, char-acterized by “lead-pipe” rigidity, hyperthermia, and autonomic instability.


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Basic & Clinical Pharmacology : Management of the Poisoned Patient : Toxic Syndromes: Antipsychotics |


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