The Lymphatic System, Immunity,
and Aging
As an individual ages, the resistance to all types of infection is
decreased. Malignancies are more com-mon in the elderly. The immune response to
vaccines is also diminished. The incidence of autoimmune diseases increases,
which may be a result of the over-all decrease in immune function. Natural
killer cell activity decreases, leading to the proliferation of ab-normal cells
such as cancer cells. The number of T lymphocytes diminishes with age. Both T
and B lym-phocytes become less responsive to antigens; atro-phy of the thymus
with resultant decrease in hor-mone secretion may play a part in this decreased
response. B cell function is decreased and the quan-tity of antibodies produced
when the body is chal-lenged with antigens is reduced.
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