Specific Nephrotoxins
·
Aminoglycosides
· Amphotericin
· NSAIDs: ® ¯PGs which vasodilate afferent arteriole ® vasoconstriction. Compounded risk if already dehydrated, elderly, etc
· ACE inhibitors. Acute renal failure following introduction of ACE ® ?renal artery stenosis: already reduced renal flow, ACE dilates efferent arteriole ® precipitous fall in GFR.
·
All radio-contrasts: ¯risk in
at risk patients by maintaining hydration with a saline drip
·
Chemotherapy: eg Cisplatin
·
Rhabdomyolysis (from trauma,
status epilepticus, acidosis, etc):
o Injury to membrane of skeletal muscle
o ® Ck
o ® Renal failure due to combined effect of nephrotoxic effect of myoglobin, hypovolaemia and aciduria
o Urinalysis is +ive for blood but no RBCs on microscopy. Urine is dark brown
Related Topics
Privacy Policy, Terms and Conditions, DMCA Policy and Compliant
Copyright © 2018-2024 BrainKart.com; All Rights Reserved. Developed by Therithal info, Chennai.