Placental Site Tumors

PLACENTAL SITE TUMORS

Placental site tumor is a rare form of trophoblastic disease. The tumor is comprised of monomorphic populations of intermediate cytotrophoblastic cells that are locally inva-sive at the site of placental implantation. The tumor only secretes small amounts of hCG, and can be better fol-lowed by human placental lactogen levels. This tumor is rarely metastatic and is much more resistant to standard chemotherapy. Hysterectomy as initial therapy is often curative